Quercetin Phytosome

About Quercetin Phytosome

An antioxidant flavonoid that supports balanced immune function, inflammatory response, and histamine release*

Quercetin is a flavonoid found in many plant-based foods – onions having the highest amount. Other fruits and vegetables that contain significant amounts of quercetin include apples, berries, grapes, and green leafy vegetables. As ubiquitous as quercetin is in nature, it also has wide-ranging benefits in the body. One important actions is to strengthen mast cell membranes (a type of white blood cell), which down-regulates the release of histamine, providing nutritional support for skin sensitivity (like hives) and seasonal allergies.* Quercetin also has important antioxidant activities and supports balanced immune function and inflammatory response – all of which provide benefit for respiratory health, athletic performance, healthy aging, and more.*

New research is emerging that supports quercetin’s role in healthy aging.* Quercetin is the first natural substance to be identified as a senolytic – a substance that clears worn out, dysfunctional cells (senescent cells) from the body.*Senescent cells have been identified as a major contributor to the aging process.

The Thorne Difference

In its unbound form, quercetin is known for its poor absorption. The crucial advantage attributable to quercetin phytosome is that it’s made using advanced phytosome technology. Phytosome complexes are created by a patented process that binds a botanical constituent (in this case quercetin) to phospholipids that are key components of cell membranes. In the case of quercetin phytosome, the quercetin is combined with sunflower-sourced phospholipids, thus creating a phytosome complex that can easily cross the gut barrier. A recent study found up to 20-times greater blood levels of quercetin following ingestion of quercetin phytosome compared to unbound quercetin.

The Science

Respiratory and Immune Support

Quercetin phytosome: a pilot registry.. Minerva Med 2019;110(6):524-529.. Cesarone M, Belcaro G, Hu S, et al...

Possible therapeutic effects of adjuvant quercetin supplementation.... Int J Gen Med 2021;14:2359-2366.. Di Pierro F, Derosa G, Maffioli P, et al.

Interactions

Interaction study between antiplatelet agents, anticoagulants, diabetic therapy and a novel delivery form of quercetin.. Minerva Cardioangiol 2019;67(1):79-83.. Riva A, Corti A, Belcaro G, et al.

Allergy Support

Soothing and anti-itch effect of quercetin phytosome in human subjects: a single-blind study.. Clin Cosmet Investig Dermatol 2016;9:55-62. . Maramaldi G, Togni S, Pagin I, et al.

Quercetin phytosome reduces the wheal response to histamine injection.. Esperienze Dermatol 2020;22(1):5-9.. Belcaro G, Cesarone M, Scipione C, et al

Effects of repeated oral intake of the quercetin-containing supplement on allergic reaction – randomized, placebo-controlled, double-blind parallel-group study.. Jpn Pharmacol Ther 2020;48(11):1945-1959.. Yamada S, Shirai M, Inaba Y, Takara T.

Healthy Aging

Cellular senescence in.... Curr Mol Biol Rep. 2021;1-10. . Kellogg DL, Kellogg DL Jr, Musi N, Nambiar AM

Quercetin prevents oxidative stress-induced injury of periodontal ligament cells.... Drug Des Devel Ther. 2021 Aug 12;15:3509-3522. . Wei Y, Fu J, Wu W, et al.

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of dasatinib plus quercetin in individuals.... EBioMedicine. 2019;47:446-456.. Hickson LJ, Langhi Prata LGP, et al.

Athletic Performance

Quercetin Phytosome® in triathlon athletes: a pilot registry study.. Minerva Med 2018;109(4):285-289.. Riva A, Vitale J, Belcaro G, et al.

Absorption

Improved oral absorption of quercetin from Quercetin Phytosome®, a new delivery system based on food grade lecithin.. Eur J Drug Metab Pharmacokinet 2019;44(2):169-177.. Riva A, Ronchi M, Petrangolini G, et al.